American Heart Association teams with Duke Clinical Research Institute to conduct pragmatic clinical trials and pursue implementation science

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Innovative collaboration will enable real-world data from American Heart Association’s Get With the Guidelines programs to power future clinical research and improve patient outcomes

A new collaboration building on the strengths of the American Heart Association and the Duke Clinical Research Institute (DCRI) in cardiovascular research and data science will deliver insights to enhance quality of treatment for cardiovascular disease and improve patient outcomes.

The American Heart Association, the leading voluntary health organization devoted to a world of longer, healthier lives, collects patient data from more than 2,000 hospitals in its Get With The Guidelines (GWTG) quality improvement programs. The Association and the DCRI will collaborate to design and conduct pragmatic randomized clinical trials in existing real-world nationwide registries. In addition to pragmatic trials, the strategic alliance will also investigate implementation of best-practices to treat cardiovascular illness, improve outcomes, and reduce suffering.

The DCRI is a leader in pragmatic approaches in clinical research. The DCRI, in collaboration with PCORnet, pioneered the ADAPTABLE study, which recently completed enrollment of 15,000 patients using real-world data from electronic health records.

“We are delighted to expand our collaboration and research initiatives with the American Heart Association. Our experience in conducting pragmatic trials makes the DCRI a logical partner for applying pragmatic clinical design approaches with Association’s data-rich Get With The Guidelines program. By uniting our experience and leadership in clinical trials and operational expertise with the Association’s repository and experience in quality improvement, together we can create new clinical evidence and glean insights that will advance cardiovascular health, inform treatment guidelines, and accelerate the adoption of scientific discoveries into clinical practice,” said Jonathan Piccini, M.D., MHS, the principal investigator of the GWTG analytic center at the DCRI.

“The role of real-world data and real-world evidence in health care decision making is continuing to grow,” said John Warner, executive vice president for health system affairs at UT Southwestern and American Heart Association volunteer expert.  “This new collaboration with the DCRI will help us to more effectively use our patient-level and hospital-level data to not only inform guideline developments but also generate new and innovative treatment approaches.”

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